1. Chronic toxicity and carcinogenicity studies of ethylene thiourea (ETU), 97% pure, had been performed in F344/N rats and B6C3F1 mice of each intercourse. (+)-(1S,4R)-P-MENTHA-2,8-DIEN-1-OL producer of the study was to determine if incorporation of perinatal publicity, in addition to the standard publicity of younger grownup animals for two years, enhances the sensitivity of the bioassay in identification of the carcinogenic potential of chemicals when compared to the typical publicity of animals to a chemical for two years, usually beginning on the age of 6-eight weeks. The research had been designed to find out (1) the toxic and carcinogenic results of dietary ETU in rats and mice receiving perinatal exposure up to 8 weeks of age followed by management weight-reduction plan for two years, (2) the results of ETU in rats and mice receiving exposure for 2 years beginning on the age of 8 weeks, and (3) the results of combined perinatal/adult exposure to ETU (perinatal exposure to eight weeks of age followed by the grownup exposure for two years). During the perinatal interval, rats had been uncovered to dietary ETU concentrations ranging from 9 to ninety ppm and adult publicity concentrations ranged from 25 to 250 ppm. Within the mice, the perinatal publicity concentrations of ETU in the eating regimen ranged from 33 to 330 ppm, and in the adults the concentrations have been a hundred to one thousand ppm. A total of eight publicity teams (together with controls) had been used with 60 animals in each group. Ten animals from every group had been killed at Month 9 of the examine for interim analysis. The thyroid gland in rats and mice and the liver in mice were identified as target organs of ETU toxicity on the 9-month interim analysis. The perinatal solely exposure to ETU was not carcinogenic in rats or mice, whereas adult or perinatal/adult mixture exposures to ETU have been carcinogenic each in rats and in mice. The thyroid gland was the foremost site of ETU carcinogenicity both in rats and in mice. The liver and pituitary glands had been other main websites of ETU carcinogenicity in mice. The carcinogenic results of ETU had been typically comparable by grownup and perinatal/adult mixture protocols besides that the incidences of thyroid tumors had been slightly greater in the rats receiving the perinatal/adult combination of ETU exposure in the food regimen.
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