and
Parkinson's, glyphosate application
since the beginning of Glyphosate application and GMO plantings due to the health problems related
to Parkinson's. graph
Additional info: http://www.earthopensource.org/ ("GMO Myths and Truths")
Published online in: www.intertox.sav.sk & www.versita.com/it ~ Copyright © 2013 SETOX &
Extra source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/pdf/ITX-6-159.pdf
ISSN: 1337-6853 (print version) | 1337-9569 (electronic version)
This is an Open Access article distributed under the terms of the Creative Commons Attribution
License (http://creativecommons.org/licenses/by/2.0 ), which permits unrestricted
use,distribution, and reproduction in any medium, provided the original work is properly
Citation: Samsel, A., & Seneff, S. (2013). Glyphosate, pathways to modern diseases II: Celiac
sprue and gluten intolerance. Interdisciplinary Toxicology, 6(4), 159–184.
http://doi.org/10.2478/intox-2013-0026
Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance
Anthony SAMSEL 1 and Stephanie SENEFF 2
1 Independent Scientist and Consultant, Deerfield, NH 03037, USA
2 Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, USA
ITX060413R01 •Received: 24 September 2013 •Revised: 10 November 2013 •Accepted: 12 November 2013
Celiac disease, and, more generally, gluten intolerance, is a growing problem worldwide, but
especially in North America and Europe, where an estimated 5% of the population now suffers from
it. Symptoms include nausea, diarrhea, skin rashes, macrocytic anemia and depression. It is a
multifactorial disease associated with numerous nutritional deficiencies as well as reproductive
issues and increased risk to thyroid disease, kidney failure and cancer. Here, we propose that
glyphosate, the active ingredient in the herbicide, Roundup®, is the most important causal factor
in this epidemic. Fish exposed to glyphosate develop digestive problems that are reminiscent of
celiac disease. Celiac disease is associated with imbalances in gut bacteria that can be fully
explained by the known effects of glyphosate on gut bacteria. Characteristics of celiac disease
point to impairment in many cytochrome P450 enzymes, which are involved with detoxifying
environmental toxins, activating vitamin D3, catabolizing vitamin A, and maintaining bile acid
production and sulfate supplies to the gut. Glyphosate is known to inhibit cytochrome P450
enzymes. Deficiencies in iron, cobalt, molybdenum, copper and other rare metals associated with
celiac disease can be attributed to glyphosate’s strong ability to chelate these elements.
Deficiencies in tryptophan, tyrosine, methionine and selenomethionine associated with celiac
disease match glyphosate’s known depletion of these amino acids. Celiac disease patients have an
increased risk to non-Hodgkin’s lymphoma, which has also been implicated in glyphosate exposure.
Reproductive issues associated with celiac disease, such as infertility, miscarriages, and birth
defects, can also be explained by glyphosate. Glyphosate residues in wheat and other crops are
likely increasing recently due to the growing practice of crop desiccation just prior to the
harvest. We argue that the practice of “ripening” sugar cane with glyphosate may explain the
recent surge in kidney failure among agricultural workers in Central America. We conclude with a
plea to governments to reconsider policies regarding the safety of glyphosate residues in foods."
source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/pdf/ITX-6-159.
ISSN: 1337-6853 (print version) | 1337-9569 (electronic version)
"Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies
Citation: Samsel, A., & Seneff, S.
sprue
neurological diseases, and
http://doi.org/10.
Extra Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/
Abstract
Manganese (Mn) is an often overlooked but important nutrient, required in small amounts for
multiple essential functions in the body. A recent study on cows fed genetically modified
Roundup®-Ready feed revealed a severe depletion of serum Mn. Glyphosate, the active ingredient in
Roundup®, has also been shown to severely deplete Mn levels in plants. Here, we investigate the
impact of Mn on physiology, and its association with gut dysbiosis as well as neuropathologies
such as autism, Alzheimer's disease (AD), depression, anxiety syndrome, Parkinson's disease (PD),
and prion diseases. Glutamate overexpression in the brain in association with autism, AD, and
other neurological diseases can be explained by Mn deficiency. Mn superoxide dismutase protects
mitochondria from oxidative damage, and mitochondrial dysfunction is a key feature of autism and
Alzheimer’s. Chondroitin sulfate synthesis depends on Mn, and its deficiency leads to osteoporosis
and osteomalacia. Lactobacillus, depleted in autism, depend critically on Mn for antioxidant
protection. Lactobacillus probiotics can treat anxiety, which is a comorbidity of autism and
chronic fatigue syndrome. Reduced gut Lactobacillus leads to overgrowth of the pathogen,
Salmonella, which is resistant to glyphosate toxicity, and Mn plays a role here as well. Sperm
motility depends on Mn, and this may partially explain increased rates of infertility and birth
defects. We further reason that, under conditions of adequate Mn in the diet, glyphosate, through
its disruption of bile acid homeostasis, ironically promotes toxic accumulation of Mn in the
brainstem, leading to conditions such as PD and prion diseases.
...A major consideration is that our gut bacteria do have the shikimate pathway, and that we
depend upon this pathway in our gut bacteria as well as in plants to supply us with the essential
aromatic amino acids, tryptophan, tyrosine, and phenylalanine. Methionine, an essential sulfur-
containing amino acid, and glycine, are also negatively impacted by glyphosate. Furthermore, many
other biologically active molecules, including serotonin, melatonin, melanin, epinephrine,
dopamine, thyroid hormone, folate, coenzyme Q10, vitamin K, and vitamin E, depend on the shikimate
pathway metabolites as precursors. Gut bacteria and plants use exclusively the shikimate pathway
to produce these amino acids. In part because of shikimate pathway disruption, our gut bacteria
are harmed by glyphosate, as evidenced by the fact that it has been patented as an antimicrobial
agent.[298]
...Adjuvants in pesticides are synergistically toxic with the active ingredient. Mesnage et al.
[189] showed that Roundup® was 125 times more toxic than glyphosate by itself. These authors
wrote: “Despite its relatively benign reputation, Roundup® was among the most toxic herbicides and
insecticides tested.”[189]
The industry dictates that 3 months is a sufficiently long time to test for toxicity in rodent
studies, and as a consequence none of the industry studies have run for longer than 3 months. The
only study we are aware of that was a realistic assessment of the long-term effects of GM
Roundup®-Ready corn and soy feed on mammals was the study by Séralini et al. that examined the
effects on rats fed these foods for their entire life span.[261] This study showed increased risk
to mammary tumors in females, as well as kidney and liver damage in the males, and a shortened
lifespan in both females and males. These effects occurred both in response to Roundup and to the
GM food alone. These effects only began to be apparent after 4 months."
[189] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/#ref189
Major pesticides are more toxic to human cells than their declared active principles.
Mesnage R, Defarge N, Spiroux de Vendômois J, Séralini GE
Biomed Res Int. 2014; 2014():179691.
[261] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/#ref261
Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize.
Séralini GE, Clair E, Mesnage R, Gress S, Defarge N, Malatesta M, Hennequin D, de Vendômois JS
Food Chem Toxicol. 2012 Nov; 50(11):4221-31.
[298] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/#ref298 US Patent number 7,771,736 B2.
Glyphosate formulations and their use for the inhibition of 5-enolpyruvylshikimate-3-phosphate synthase.
Publication date: August 10. 2010. [Last accessed on 2014 Jun 30]. Available from: http://www.google.com/patents/US7771736
Confirmed, FDA illegally allowed GE foods into market without proper GRAS
qualification and illegally perpetuated flagrant abuse of U.S. Law to serve Biotech interests!
source: https://www.organicconsumers.
foods-fraudulent-and-illegal-0
"29. Although the FDA has been illegally, and fraudulently, exempting GE
foods from the testing requirements established by Congress in 1958,
hardly any current members of Congress are aware of the malfeasance.
Consequently, the House of Representatives (in passing a bill titled the
“Safe and Accurate Food Labeling Act of 2015”) voted to remove the
requirements that the FDA has been illicitly waiving; and it appears
that virtually none of those who voted “yes” realized that they were in
essence forgiving the FDA’s flagrant violation of the law (and its
snubbing of the Congressional will) – and legitimizing a policy that was
deemed both unscientific and risky by the agency’s own experts.* ...*
Although the provisions of the bill that have garnered most attention
are those that relate to labeling (especially the one that prohibits
states from requiring the labeling of GMOs sold within their borders),
the provision that legitimizes the FDA’s lax and illegal no-testing
policy is the one that alters current statutory law."
"We’ve identified five Senators who we think are most likely to lend Monsanto a
helping hand. They are: Sen. Roy Blunt (R-Mo.), author of the 2013
Monsanto Protection Act; Senate Appropriations Committee Chairman Thad
Cochran (R-Miss.), who blocked repeal of the 2013 Monsanto Protection
Act and could stick the DARK Act into a must-pass spending bill; Senate
Agriculture Committee Chairman Pat Roberts (R-Kan.) and Agriculture
Committee member Chuck Grassley (R-Iowa), DARK Act supporters who could
attach H.R. 1599 to the Child Nutrition Act; and Senate Majority Leader
Mitch McConnell (R-Ky.), who has the power to allow the DARK Act to get a
Senate vote as an amendment to another piece of legislation."
Petition: http://salsa3.salsalabs.com/o/50865/p/dia/action3/common/public/?action_KEY=17431
~ source: http://truthwiki.org/usda-and-monsanto-biotech-industry-collusion/
"The misinformation campaign of the USDA Food and Nutrition Service: SNAP,
the Supplemental Nutrition Assistance Program, provides free government
money for families with low income who mainly purchase toxic, processed
and genetically modified food and toxic beverages from conventional
grocers. Nearly one sixth, or 50,000,000 Americans are currently under
the “auspice” of this program that virtually handicaps a large portion
of the population, and basically “sells them out” to large corporations
that feed toxicity to humans and the environment daily.
Even homeless people believe that conventional food is safe for consumption,
thanks to the USDA. USDA “aid” can be funneled through foreign
governments, USAID and the World Food Program, and according to the Agricultural Act of 1949,
the USDA is provided with legal basis for these actions. Pay it forward sixty
years, and now the USDA dabbles in controlling food sales to domestic
and world markets, and provides genetically modified (cancer-causing)
food to needy countries around the world, who usually are also
influenced to be inoculated with untested, toxic vaccines pushed by the
CDC and the auspicious, infamous Bill & Melinda Gates Foundation"
~ source: http://truthwiki.
This is all we need
180% Increase in health issues and subsequent death (from 1990 to
and
Parkinson's, glyphosate application
since the beginning of Glyphosate application and GMO plantings due to the health problems related
to Parkinson's. graph
Additional info: http://www.earthopensource.org/ ("GMO Myths and
"Long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize
by Gilles-Eric Séralini*, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela
Malatesta, Didier Hennequin and Joël Spiroux de Vendômois
* Corresponding author: Gilles-Eric Séralini [email protected]
source: http://www.enveurope.com/content/26/1/14
Received: 22 March 2014 Accepted: 16 May 2014 Published: 24 June 2014
© 2014 Séralini et al.; licensee Springer
This is an Open Access article distributed under the terms of the Creative Commons Attribution
License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background
The health effects of a Roundup-tolerant NK603 genetically modified (GM) maize (from 11% in the
diet), cultivated with or without Roundup application and Roundup alone (from 0.1 ppb of the full
pesticide containing glyphosate and adjuvants) in drinking water, were evaluated for 2 years in
rats. This study constitutes a follow-up investigation of a 90-day feeding study conducted by
Monsanto in order to obtain commercial release of this GMO, employing the same rat strain and
analyzing biochemical parameters on the same number of animals per group as our investigation. Our
research represents the first chronic study on these substances, in which all observations
including tumors are reported chronologically. Thus, it was not designed as a carcinogenicity
study. We report the major findings with 34 organs observed and 56 parameters analyzed at 11 time
points for most organs.
Results
Biochemical analyses confirmed very significant chronic kidney deficiencies, for all treatments
and both sexes; 76% of the altered parameters were kidney-related. In treated males, liver
congestions and necrosis were 2.5 to 5.5 times higher. Marked and severe nephropathies were also
generally 1.3 to 2.3 times greater. In females, all treatment groups showed a two- to threefold
increase in mortality, and deaths were earlier. This difference was also evident in three male
groups fed with GM maize. All results were hormone- and sex-dependent, and the pathological
profiles were comparable. Females developed large mammary tumors more frequently and before
controls; the pituitary was the second most disabled organ; the sex hormonal balance was modified
by consumption of GM maize and Roundup treatments. Males presented up to four times more large
palpable tumors starting 600 days earlier than in the control group, in which only one tumor was
noted. These results may be explained by not only the non-linear endocrine-disrupting effects of
Roundup but also by the overexpression of the EPSPS transgene or other mutational effects in the
GM maize and their metabolic consequences.
Conclusion
Our findings imply that long-term (2 year) feeding trials need to be conducted to thoroughly
evaluate the safety of GM foods and pesticides in their full commercial formulations."
source: http://www.enveurope.com/content/pdf/s12302-014-0014-5.pdf