1. 180% Increase in health issues and subsequent death (from 1990 to 2010) associated with
2. Parkinson's, glyphosate application and GMO crops: http://imgur.com/FrULVaZ
3. Graph from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/pdf/ITX-6-159.pdf
4. Additional info: http://www.earthopensource.org/ ("GMO Myths and Truths")
5.  
6. "Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance
7. Interdiscip Toxicol. 2013; Vol. 6(4): 159–184. doi: 10.2478/intox-2013-0026
8. Published online in: www.intertox.sav.sk & www.versita.com/it ~ Copyright © 2013 SETOX & IEPT, SASc.
9. Extra source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/pdf/ITX-6-159.pdf
10. ISSN: 1337-6853 (print version) | 1337-9569 (electronic version)
11. This is an Open Access article distributed under the terms of the Creative Commons Attribution
12. License (http://creativecommons.org/licenses/by/2.0 ), which permits unrestricted
13. use,distribution, and reproduction in any medium, provided the original work is properly cited.
14.  
15. Citation: Samsel, A., & Seneff, S. (2013). Glyphosate, pathways to modern diseases II: Celiac
16. sprue and gluten intolerance. Interdisciplinary Toxicology, 6(4), 159–184.
17. http://doi.org/10.2478/intox-2013-0026
18.  
19. ABSTRACT
20. Celiac disease, and, more generally, gluten intolerance, is a growing problem worldwide, but
21. especially in North America and Europe, where an estimated 5% of the population now suffers from
22. it. Symptoms include nausea, diarrhea, skin rashes, macrocytic anemia and depression. It is a
23. multifactorial disease associated with numerous nutritional deficiencies as well as reproductive
24. issues and increased risk to thyroid disease, kidney failure and cancer. Here, we propose that
25. glyphosate, the active ingredient in the herbicide, Roundup®, is the most important causal factor
26. in this epidemic. Fish exposed to glyphosate develop digestive problems that are reminiscent of
27. celiac disease. Celiac disease is associated with imbalances in gut bacteria that can be fully
28. explained by the known effects of glyphosate on gut bacteria. Characteristics of celiac disease
29. point to impairment in many cytochrome P450 enzymes, which are involved with detoxifying
30. environmental toxins, activating vitamin D3, catabolizing vitamin A, and maintaining bile acid
31. production and sulfate supplies to the gut. Glyphosate is known to inhibit cytochrome P450
32. enzymes. Deficiencies in iron, cobalt, molybdenum, copper and other rare metals associated with
33. celiac disease can be attributed to glyphosate’s strong ability to chelate these elements.
34. Deficiencies in tryptophan, tyrosine, methionine and selenomethionine associated with celiac
35. disease match glyphosate’s known depletion of these amino acids. Celiac disease patients have an
36. increased risk to non-Hodgkin’s lymphoma, which has also been implicated in glyphosate exposure.
37. Reproductive issues associated with celiac disease, such as infertility, miscarriages, and birth
38. defects, can also be explained by glyphosate. Glyphosate residues in wheat and other crops are
39. likely increasing recently due to the growing practice of crop desiccation just prior to the
40. harvest. We argue that the practice of “ripening” sugar cane with glyphosate may explain the
41. recent surge in kidney failure among agricultural workers in Central America. We conclude with a
42. plea to governments to reconsider policies regarding the safety of glyphosate residues in foods."
43. source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/pdf/ITX-6-159.pdf
44.  
45.  
46. "Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies
47. Citation: Samsel, A., & Seneff, S. (2015). Glyphosate, pathways to modern diseases III: Manganese,
48. neurological diseases, and associated pathologies. Surgical Neurology International, 6, 45.
49. http://doi.org/10.4103/2152-7806.153876
50. Extra Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/
51.  
52. Abstract
53. Manganese (Mn) is an often overlooked but important nutrient, required in small amounts for
54. multiple essential functions in the body. A recent study on cows fed genetically modified
55. Roundup®-Ready feed revealed a severe depletion of serum Mn. Glyphosate, the active ingredient in
56. Roundup®, has also been shown to severely deplete Mn levels in plants. Here, we investigate the
57. impact of Mn on physiology, and its association with gut dysbiosis as well as neuropathologies
58. such as autism, Alzheimer's disease (AD), depression, anxiety syndrome, Parkinson's disease (PD),
59. and prion diseases. Glutamate overexpression in the brain in association with autism, AD, and
60. other neurological diseases can be explained by Mn deficiency. Mn superoxide dismutase protects
61. mitochondria from oxidative damage, and mitochondrial dysfunction is a key feature of autism and
62. Alzheimer’s. Chondroitin sulfate synthesis depends on Mn, and its deficiency leads to osteoporosis
63. and osteomalacia. Lactobacillus, depleted in autism, depend critically on Mn for antioxidant
64. protection. Lactobacillus probiotics can treat anxiety, which is a comorbidity of autism and
65. chronic fatigue syndrome. Reduced gut Lactobacillus leads to overgrowth of the pathogen,
66. Salmonella, which is resistant to glyphosate toxicity, and Mn plays a role here as well. Sperm
67. motility depends on Mn, and this may partially explain increased rates of infertility and birth
68. defects. We further reason that, under conditions of adequate Mn in the diet, glyphosate, through
69. its disruption of bile acid homeostasis, ironically promotes toxic accumulation of Mn in the
70. brainstem, leading to conditions such as PD and prion diseases.
71.  
72. ...A major consideration is that our gut bacteria do have the shikimate pathway, and that we
73. depend upon this pathway in our gut bacteria as well as in plants to supply us with the essential
74. aromatic amino acids, tryptophan, tyrosine, and phenylalanine. Methionine, an essential sulfur-
75. containing amino acid, and glycine, are also negatively impacted by glyphosate. Furthermore, many
76. other biologically active molecules, including serotonin, melatonin, melanin, epinephrine,
77. dopamine, thyroid hormone, folate, coenzyme Q10, vitamin K, and vitamin E, depend on the shikimate
78. pathway metabolites as precursors. Gut bacteria and plants use exclusively the shikimate pathway
79. to produce these amino acids. In part because of shikimate pathway disruption, our gut bacteria
80. are harmed by glyphosate, as evidenced by the fact that it has been patented as an antimicrobial
81. agent.[298]
82.  
83. ...Adjuvants in pesticides are synergistically toxic with the active ingredient. Mesnage et al.
84. [189] showed that Roundup® was 125 times more toxic than glyphosate by itself. These authors
85. wrote: “Despite its relatively benign reputation, Roundup® was among the most toxic herbicides and
86. insecticides tested.”[189]
87.  
88. The industry dictates that 3 months is a sufficiently long time to test for toxicity in rodent
89. studies, and as a consequence none of the industry studies have run for longer than 3 months. The
90. only study we are aware of that was a realistic assessment of the long-term effects of GM
91. Roundup®-Ready corn and soy feed on mammals was the study by Séralini et al. that examined the
92. effects on rats fed these foods for their entire life span.[261] This study showed increased risk
93. to mammary tumors in females, as well as kidney and liver damage in the males, and a shortened
94. lifespan in both females and males. These effects occurred both in response to Roundup and to the
95. GM food alone. These effects only began to be apparent after 4 months."
96.  
97. [189] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/#ref189
98. Major pesticides are more toxic to human cells than their declared active principles.
99. Mesnage R, Defarge N, Spiroux de Vendômois J, Séralini GE
100. Biomed Res Int. 2014; 2014():179691.
101. [261] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/#ref261
102. Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize.
103. Séralini GE, Clair E, Mesnage R, Gress S, Defarge N, Malatesta M, Hennequin D, de Vendômois JS
104. Food Chem Toxicol. 2012 Nov; 50(11):4221-31.
105. [298] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/#ref298 US Patent number 7,771,736 B2.
106. Glyphosate formulations and their use for the inhibition of 5-enolpyruvylshikimate-3-phosphate synthase.
107. Publication date: August 10. 2010. [Last accessed on 2014 Jun 30]. Available from: http://www.google.com/patents/US7771736
108.  
109.  
110. Confirmed, FDA illegally allowed GE foods into market without proper GRAS
111. qualification and illegally perpetuated flagrant abuse of U.S. Law to serve Biotech interests!
112. source: https://www.organicconsumers.org/news/why-fda%E2%80%99s-policy-genetically-engineered-foods-fraudulent-and-illegal-0
113. "29. Although the FDA has been illegally, and fraudulently, exempting GE
114. foods from the testing requirements established by Congress in 1958,
115. hardly any current members of Congress are aware of the malfeasance.
116. Consequently, the House of Representatives (in passing a bill titled the
117.  “Safe and Accurate Food Labeling Act of 2015”) voted to remove the
118. requirements that the FDA has been illicitly waiving; and it appears
119. that virtually none of those who voted “yes” realized that they were in
120. essence forgiving the FDA’s flagrant violation of the law (and its
121. snubbing of the Congressional will) – and legitimizing a policy that was
122.  deemed both unscientific and risky by the agency’s own experts.* ...*
123. Although the provisions of the bill that have garnered most attention
124. are those that relate to labeling (especially the one that prohibits
125. states from requiring the labeling of GMOs sold within their borders),
126. the provision that legitimizes the FDA’s lax and illegal no-testing
127. policy is the one that alters current statutory law."
128.  
129. "We’ve identified five Senators who we think are most likely to lend Monsanto a
130.  helping hand. They are: Sen. Roy Blunt (R-Mo.), author of the 2013
131. Monsanto Protection Act; Senate Appropriations Committee Chairman Thad
132. Cochran (R-Miss.), who blocked repeal of the 2013 Monsanto Protection
133. Act and could stick the DARK Act into a must-pass spending bill; Senate
134. Agriculture Committee Chairman Pat Roberts (R-Kan.) and Agriculture
135. Committee member Chuck Grassley (R-Iowa), DARK Act supporters who could
136. attach H.R. 1599 to the Child Nutrition Act; and Senate Majority Leader
137. Mitch McConnell (R-Ky.), who has the power to allow the DARK Act to get a
138.  Senate vote as an amendment to another piece of legislation."
139. Petition: http://salsa3.salsalabs.com/o/50865/p/dia/action3/common/public/?action_KEY=17431
140.  
141. ~ source: http://truthwiki.org/usda-and-monsanto-biotech-industry-collusion/
142. "The misinformation campaign of the USDA Food and Nutrition Service: SNAP,
143. the Supplemental Nutrition Assistance Program, provides free government
144. money for families with low income who mainly purchase toxic, processed
145. and genetically modified food and toxic beverages from conventional
146. grocers. Nearly one sixth, or 50,000,000 Americans are currently under
147. the “auspice” of this program that virtually handicaps a large portion
148. of the population, and basically “sells them out” to large corporations
149. that feed toxicity to humans and the environment daily.
150. Even homeless people believe that conventional food is safe for consumption,
151.  thanks to the USDA. USDA “aid” can be funneled through foreign
152. governments, USAID and the World Food Program, and according to the Agricultural Act of 1949,
153. the USDA is provided with legal basis for these actions. Pay it forward sixty
154. years, and now the USDA dabbles in controlling food sales to domestic
155. and world markets, and provides genetically modified (cancer-causing)
156. food to needy countries around the world, who usually are also
157. influenced to be inoculated with untested, toxic vaccines pushed by the
158. CDC and the auspicious, infamous Bill & Melinda Gates Foundation"
159. ~ source: http://truthwiki.org/usda-and-monsanto-biotech-industry-collusion/
160.  
161.  
162. 180% Increase in health issues and subsequent death (from 1990 to 2010) associated with
163. Parkinson's, glyphosate application and gmo crops: http://imgur.com/FrULVaZ
164. Graph from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/pdf/ITX-6-159.pdf
165.  
166. Additional info: http://www.earthopensource.org/ ("GMO Myths and Truths")
167.  
168.  
169. "Long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize
170.  by Gilles-Eric Séralini*, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela
171.     Malatesta, Didier Hennequin and Joël Spiroux de Vendômois
172.     * Corresponding author: Gilles-Eric Séralini [email protected]
173. source: http://www.enveurope.com/content/26/1/14
174. Received:       22 March 2014 Accepted: 16 May 2014 Published:  24 June 2014
175. © 2014 Séralini et al.; licensee Springer
176. This is an Open Access article distributed under the terms of the Creative Commons Attribution
177. License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use,
178. distribution, and reproduction in any medium, provided the original work is properly cited.
179.  
180. Abstract
181.  
182. Background
183. The health effects of a Roundup-tolerant NK603 genetically modified (GM) maize (from 11% in the
184. diet), cultivated with or without Roundup application and Roundup alone (from 0.1 ppb of the full
185. pesticide containing glyphosate and adjuvants) in drinking water, were evaluated for 2 years in
186. rats. This study constitutes a follow-up investigation of a 90-day feeding study conducted by
187. Monsanto in order to obtain commercial release of this GMO, employing the same rat strain and
188. analyzing biochemical parameters on the same number of animals per group as our investigation. Our
189. research represents the first chronic study on these substances, in which all observations
190. including tumors are reported chronologically. Thus, it was not designed as a carcinogenicity
191. study. We report the major findings with 34 organs observed and 56 parameters analyzed at 11 time
192. points for most organs.
193.  
194.  
195. Results
196. Biochemical analyses confirmed very significant chronic kidney deficiencies, for all treatments
197. and both sexes; 76% of the altered parameters were kidney-related. In treated males, liver
198. congestions and necrosis were 2.5 to 5.5 times higher. Marked and severe nephropathies were also
199. generally 1.3 to 2.3 times greater. In females, all treatment groups showed a two- to threefold
200. increase in mortality, and deaths were earlier. This difference was also evident in three male
201. groups fed with GM maize. All results were hormone- and sex-dependent, and the pathological
202. profiles were comparable. Females developed large mammary tumors more frequently and before
203. controls; the pituitary was the second most disabled organ; the sex hormonal balance was modified
204. by consumption of GM maize and Roundup treatments. Males presented up to four times more large
205. palpable tumors starting 600 days earlier than in the control group, in which only one tumor was
206. noted. These results may be explained by not only the non-linear endocrine-disrupting effects of
207. Roundup but also by the overexpression of the EPSPS transgene or other mutational effects in the
208. GM maize and their metabolic consequences.
209.  
210. Conclusion
211. Our findings imply that long-term (2 year) feeding trials need to be conducted to thoroughly
212. evaluate the safety of GM foods and pesticides in their full commercial formulations."
213. source: http://www.enveurope.com/content/pdf/s12302-014-0014-5.pdf